Jason Michael Grilli (born November 11, 1976) is an American former professional baseball pitcher. He played in Major League Baseball (MLB) for the Florida Marlins, Chicago White Sox, Detroit Tigers, Colorado Rockies, Pittsburgh Pirates, Los Angeles Angels of Anaheim, Atlanta Braves, Toronto Blue Jays, and Texas Rangers.

Taken as the fourth overall selection of the 1997 MLB draft by the San Francisco Giants, Grilli was one of the top starting pitcher prospects in all of Minor League Baseball, ranked 54th in 1998 and 44th in 1999. The Giants traded him to the Florida Marlins in 1999, for whom he debuted on May 11, 2000. n 2011, Grilli's career took off as a relief pitcher with the Pittsburgh Pirates. That year, he carried a 2.48 earned run average (ERA) and 10.2 strikeouts per nine innings (K/9) rate in 32 innings pitched (IP), and further improved in 2012, when his strikeout rate climbed to 13.8. In 2013, Grilli made his first All-Star team and became Pittsburgh's closer at the age of 36. From 2011 to 2014, he compiled a 3.09 ERA with 11.9 K/9, 3.3 BB/9 and a 34.2 percent ground-ball rate in 195+1⁄3 IP.

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On May 31, 2016, the Braves traded Grilli to the Toronto Blue Jays for Sean Ratcliffe.[51] Grilli earned his first save as a Blue Jay on June 12, closing out a 10–9 win over the Baltimore Orioles.[52] On July 2, he recorded his first win as a Blue Jay in a 9–6 victory over the Cleveland Indians.[53] In 42 regular season innings with the Blue Jays, Grilli posted a 6–4 record, 3.64 ERA, and 58 strikeouts. He made five appearances in the postseason, and allowed one hit in 32⁄3 total innings.[54] On November 5, 2016, the Blue Jays picked up Grilli's $3 million option for the 2017 season.[55] In a June 3, 2017 game against the New York Yankees, Grilli gave up four home runs in a single inning of relief, becoming the first Blue Jays reliever to do so.

Grilli was recently honored by his CNY High School, Baldwinsville as well as the Syracuse Mets.